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KMID : 0366220140490010061
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Korean Journal of Hematology
2014 Volume.49 No. 1 p.61 ~ p.64
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A case of oxaliplatin-induced immune-mediated thrombocytopenia
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Suh Seong-Eun
Jang Moon-Ju
Chong So-Young
Richard H. Aster
Brian R. Curtis
Oh Do-Yeun
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Abstract
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Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-in-duced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemo-therapy with oxaliplatin.
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KEYWORD
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Oxaliplatin, Thrombocytopenia, Immune, Drug-dependent platelet antibody
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